2017 Fiscal Year Final Research Report
Induction of regeneration to hard tissue / periodontal tissue complex around the implant
| Project/Area Number |
15K11185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田口 洋一郎 大阪歯科大学, 歯学部, 准教授 (60434792)
小正 聡 大阪歯科大学, 歯学部, 講師 (70632066)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ナノ材料 / インプラント / アメロジェニン |
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| Outline of Final Research Achievements |
The purpose of this study is to develop new implant materials aiming at the regeneration of periodontal tissues as well as hard tissues by coating nano-modified titanium with amelogenin, which is one of main proteins contained in Emdogain®. We confirmed by quartz crystal microbalance evaluation that amelogenin is easy to adsorb onto the nano-modified titanium surface as a coating. Scanning electron microscopy, scanning probe microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy analyses confirmed that amelogenin coated the nano-modified titanium surface following alkali-treatment. In vitro evaluation using rat bone marrow and periodontal ligament cells revealed that the initial adhesion of both cell types and the induction of hard tissue differentiation such as cementum were improved by amelogenin coating. Additionally, the formation of new bone in implanted surrounding tissues was observed in in vivo evaluation using rat femurs.
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| Free Research Field |
歯科補綴学
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