Treatment strategy to oromandibular dystonia patients by means of transcranial magnetic stimulation

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K11201
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nihon University
• Principal Investigator: NARITA Noriyuki 日本大学, 松戸歯学部, 客員教授 (10155997)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 口顎ジストニア / 経頭蓋磁気刺激 / 近赤外光イメージング / QOL / 筋電図

Outline of Final Research Achievements

The present study evaluated the effects of repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex (M1) on quality of life (QOL) as well as cortical activities in oromandibular dystonia (OMD) with use of a MagPro system R30. As compared with healthy controls, the OMD had significantly modulated scores in the Symptom Checklist-90-R (SCL-90R) for depression and somatization, and also for dental and physical QOL. Beneficial changes obtained by application of rTMS in the OMD as compared with the preceding control condition included improved depression and somatization states shown by the SCL-90R, and dental QOL. Additional analysis also showed that rTMS improved cortical activities in the premotor cortex, supplementary motor area, and primary sensorimotor cortex, as determined by fNIRS (OMN-3000), in the OMD group. It is concluded that rTMS to M1 results in improvements in psychiatric states and dental QOL, along with associated cortical modulations in OMD.

Free Research Field

歯科神経学

Academic Significance and Societal Importance of the Research Achievements

口顎ジストニアの治療法については、未だ、国際的にも十分な検討がなされていない。本研究結果に示された、経頭蓋磁気刺激による口顎ジストニアの精神心理、口腔QOL、ならびに口顎の異常運動に関連する皮質活動性への改善効果は、口顎ジストニアへの経頭蓋磁気刺激の有効性を示唆するものと考えている。今後fMRIなどの脳機能検索を充実させ、かつ、さらなる検討を重ねることで、口顎ジストニアへの経頭蓋磁気刺激が臨床的に可能となるものと考えている。