2017 Fiscal Year Final Research Report
Bone regenerative medicine by iPS cell derived soluble paracrine factors
| Project/Area Number |
15K11213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University (2016-2017)
Nagoya University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 骨再生 / iPS細胞 / 増殖因子 / 培養上清 / 液性因子 |
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| Outline of Final Research Achievements |
Bone regeneration by the secretomes from oral mucosa derived iPS cells and bone marrow derived mesenchymal stem cells were evaluated. We used conditioned medium (CM), CM mimicked cocktail of cytokines (CC) and exosome (Exo).
CM, CC and Exo improved the migration of stem cells, angiogenesis and differentiation into osteoblast although these three did not show any statistical difference. Even in animal studies, the results of bone formation were same.
These results indicated the conditioned medium and its contents will be able to substitute the current stem cell therapy in bone regenerative medicine.
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| Free Research Field |
外科系歯学
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