A basic research on dental implants with periodontal tissue based on induction of cementblast differentiation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11219
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kagoshima University
• Principal Investigator: SAKODA Kenji 鹿児島大学, 医歯学域歯学系, 助教 (70419654)
• Co-Investigator(Kenkyū-buntansha): 白方 良典 鹿児島大学, 医歯学域歯学系, 准教授 (60359982) ; 瀬名 浩太郎 鹿児島大学, 医歯学域歯学系, 助教 (60701117)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エナメルマトリックスタンパク / SDF-1 / HIF-1

Outline of Final Research Achievements

We found that CEMP-1 expression was enhanced by stimulating mesenchymal stem cells with enamel matrix protein (EMD).
The expression of CEMP-1 involves the transcription factor HIF-1. We found that stimulation of periodontal ligament fibroblasts (HPDLF) with EMD raises HIF-1 transcriptional activity. One target molecule of HIF-1 is SDF-1. Since SDF-1 induces mesenchymal stem cells, we investigated its production.
We found that SDF-1 production increased when HPDLF were stimulated with EMD. Therefore, SDF-1 may promote periodontal regeneration by induction of mesenchymal stem cells. EMD and SDF-1 are expected to be applied to dental implant treatment.

Free Research Field

歯周病学