Influence of inflammation on Bone Regeneration

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11230
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Li Xianqi 松本歯科大学, 歯学部, 講師 (60350831)
• Co-Investigator(Kenkyū-buntansha): 高田 匡基 松本歯科大学, 歯学部, 助教 (00507684) ; 楊 静 松本歯科大学, 総合歯科医学研究所, 講師 (50410436) ; 各務 秀明 松本歯科大学, 総合歯科医学研究所, 教授 (80242866)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨再生 / 炎症サイトカイン / 骨芽細胞 / 破骨細胞 / ステロイド

Outline of Final Research Achievements

A bone regeneration model was established by compact bone derived cells (CBDCs) in immunocompetent mice, new bone formation was observed, the expression of inflammatory cytokine IL-4, IL-17 and Osterix were increased from 2 weeks to 4 weeks. The levels of IL-6 and TNF-α were keeps in high value as compared with nude mice. After steroid administration, early inflammatory cell infiltration and IL-4, TNF-α were decreased in the transplantation site. Even with steroid short-time administration, the expression of inflammatory cytokines such IL-6 were elevated, the apoptosis and TRAP positive cells were also increased.

Free Research Field

再生医学・口腔顎顔面外科学