2018 Fiscal Year Final Research Report
Development of nano capsules toward MR imaging agent
| Project/Area Number |
15K11232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Research Collaborator |
OGAWA Akiya
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | ヘミクリプトファン / ナノカプセル / ガドリニウム / MRI / 造影剤 |
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| Outline of Final Research Achievements |
Gadolinium-containing nano-capsules were synthesized and determined their structure. The obtained nano-capsules were revealed to improve the relaxivity of water compared to Gd-DTPA, mono and dinuclear gadolinium complexes. In addition, a nano-capsule bearing a tri-amide group was synthesized and determined the structure. It was clarified that an acetylcholine was encapsulated inside the cavity of nano-capsule. A nano-capsule having biphenyl linkers was synthesized and performed structure determination. It was revealed that the nano-capsule was simultaneously encapsulated three components of cobalt ion, chloroform and acetonitrile inside the cavity.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
ガドリニウムMRI造影剤は、遊離のガドリニウムイオンが組織に沈着し肝臓・骨髄などに毒性を持つことが報告されていることから、ガドリニウムイオンの濃度を増やすことなく高感度化することが望まれている。本研究成果で得られたガドリニウム内包ナノカプセルは、ガドリニウムイオンを分子状のカプセル内部に導入した初めての例であり、水の緩和度がガドリニウムイオンの内包化により向上することを示した初めての例である。本手法がガドリニウムMRI造影剤を高感度化するための新たな選択肢となると考えられる。
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