Analysis of damage-associated molecular patterns (DAMPs) in autologous tissue-engineered cartilage and its application to regenerative medicine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Fujihara Yuko 東京大学, 医学部附属病院, 助教 (50466744)
• Co-Investigator(Kenkyū-buntansha): 星 和人 東京大学, 医学部附属病院, 教授 (30344451)
• Co-Investigator(Renkei-kenkyūsha): TAKATO Tsuyoshi 東京大学, 医学部附属病院, 登録診療員 (90171454)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 軟骨再生医療 / DAMPs

Outline of Final Research Achievements

To obtain stable outcomes in regenerative medicine, quality of cells for transplantation is of great importance. Potentially, cellular stress results in the release of damage-associated molecular patterns (DAMPs), and activates immunological responses, affecting the outcomes of transplanted tissues. In this study, we intentionally prepared necrotic chondrocytes to be gradually dying and releasing DAMPs, and investigated how the viability of chondrocytes could affect the maturation of tissue-engineered cartilage. It was suggested that DAMPs from necrotic chondrocytes could prompt migration of more immune cells, worsening the maturation of tissue-engineered cartilage.

Free Research Field

軟骨再生医療