2017 Fiscal Year Final Research Report
Analysis of the cleft lip/palate development mechanism using the p53 knockout mouse with Artificial insemination frozen embryos
| Project/Area Number |
15K11237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大峡 淳 新潟大学, 医歯学系, 教授 (40266169)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口蓋裂 |
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| Outline of Final Research Achievements |
We regarded p53 gene known as tumor suppressor gene as "a guardian of the teratogenesis". It was intended to search effect of p53 on cleft lip and palate formation in the CL/Fr mouse (cleft lip and palate sensitive strain). We analyzed to use the p53 knockout CL/Fr mouse artificial insemination frozen embryos.
Cleft lip in the CL/Frp53(-/-) mouse was suggested to be caused by specific malformation without the report so far. The cleft palate in the p53(-/-) mouse was almost the clinical condition of so-called complete cleft palate, and the palatine process was found. The size of the palatine process was very small, and most of the growth to a horizontal direction was proved not to occur.
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| Free Research Field |
歯学
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