2017 Fiscal Year Final Research Report
Pathological study for the osteoporosis produced by the osteoblastic niche and hematopoietic stem cells
| Project/Area Number |
15K11246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
辻極 秀次 岡山理科大学, 理学部, 教授 (70335628)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 骨 / 顎骨壊死 / 骨粗鬆症 |
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| Outline of Final Research Achievements |
The distribution of T cells was influenced by the ovariectomy and admistrations of bisphosphonate or teriparatide. The number of CD3+ cells within the femur bone marrow of the mice was down-regulated by the ovariectomy and administration of zoledronate. However, this number was up-regulated by the administration of teriparatide.
Mineral/matrix ration was significantly increased by the administration of zoledronate within the newly formed bone in the mandible of mice, however crystallinity, relative proteoglycan content and collgen structural integrity were significantly decreased.
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| Free Research Field |
外科系歯学
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