2017 Fiscal Year Final Research Report
Clarification of mechanism of gene therapy with a Del1
| Project/Area Number |
15K11273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 癌 / 遺伝子治療 / ゲノム |
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| Outline of Final Research Achievements |
It was revealed that the cytoreduction of mouse explanted tumors were affected by cancer gene therapy with E3C1. Additionally, its effect of cytoreduction was histological change of tumor vessel in 2015. It was revealed that the gene therapy with E3C1 effected on pericyte and Tip cell of perivascular cells in 2016. It was revealed that tumor vessel fail to function. Because, the pericyte of tumor perivascular cells were effected by the gene therapy with E3C1 2017.
As above, the gene therapy with E3C1 effected the pericyte of tumor perivascular cells. Accordingly, vascular endothelial cells can not maintain for vascular lumen. Therefore, it was suggested that the effusion emigrated of intravascular.
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| Free Research Field |
がん遺伝子治療
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