Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11277
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: KONDO Tadanori 神奈川歯科大学, 歯学部, 非常勤講師 (00587727)
• Co-Investigator(Kenkyū-buntansha): 小澤 重幸 神奈川歯科大学, 大学院歯学研究科, 講師 (40434394) ; 宮本 千央 神奈川歯科大学, 大学院歯学研究科, 特任講師 (50633963)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: CXCL14 / 異常メチル化 / 頭頚部扁平上皮癌 / セツキシマブ

Outline of Final Research Achievements

The present study aimed to prove the relationship between aberrant methylation and cetuximab resistance based on the hypothesis that aberrant methylation is a factor involved as a cause of cetuximab resistance in addition to the aforementioned genetic mutations. For this study, we originally planned to conduct investigations using biopsy samples of patients administered cetuximab, but unexpectedly, we were unable to obtain any of the said biopsy samples. Instead we proved the relationship between cetuximab resistance and methylation by increasing the group using cell lines. Cells with aberrant methylation exhibited cetuximab resistance in HSC-3 as well as other cell lines.

Free Research Field

口腔外科