2017 Fiscal Year Final Research Report
Explication of carcinogenesis related gene using mapping array of oral cancer and precancerous region
| Project/Area Number |
15K11278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College (2017)
Kanagawa Dental College (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
柴原 孝彦 東京歯科大学, 歯学部, 教授 (50178919)
恩田 健志 東京歯科大学, 歯学部, 講師 (30433949)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口腔癌 / 白板症 / DNAマッピングアレイ / 癌抑制遺伝子 / ヘテロ接合性消失 |
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| Outline of Final Research Achievements |
Were histopathological, and analyzed the DNA which we obtained from an oral squamous cell carcinoma tissue of regional node-positive case pN(+) and negative case pN(-) by Mapping Array, and detected genome copy number abnormality to be common to a pN(+) case as compared with a pN(-) case, and to be found, and listed candidate metastasis-related gene which was present in theatrical company rank. As a result of Real-time PCR, an expression of Sirt1 mRNA decrease was found in 47.1% of oral squamous cell carcinoma tissue as compared with a normal oral tissue of the resection stump neighborhood.
Sirt1 had the tendency indicating the expression decrease in a pN(+) case frequently.The likelihood that Sirt1 played an important role in in progress and lymph node metastases of oral squamous cell carcinoma was suggested.
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| Free Research Field |
口腔外科学
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