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2017 Fiscal Year Final Research Report

Development of new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension

Research Project

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Project/Area Number 15K11292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionYamaguchi University

Principal Investigator

HARADA Koji  山口大学, 大学院医学系研究科, 助教 (60253217)

Research Collaborator FERDOUS Tarannum  
MINAMI Haruyasu  
FUJIWARA Rieko  
Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsmTOR阻害剤 / ラパマイシン / 5-FU / 老化防止 / 健康寿命延長 / 口腔癌
Outline of Final Research Achievements

We investigated the combined effect one of mTOR inhibitors (rapamycin, everolimus or temsirolimus) and any of conventional anticancer agents (5-FU, CDDP, DOC, PTX, C-mab or radiation). Rapamycin in combination with 5-FU exerted maximum growth inhibitory effects on OSCC cell lines and nude mice tumors. Immunohistochemical staining showed that the expressions of p16, VEGF and podoplanin were down-regulated, and the expressions of PI3K, Akt , p27, and p21 were up-regulated on nude mice tumors treated with rapamycin and 5-FU.
These findings suggested that the combined therapy of rapamycin and 5-FU might be an new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension.

Free Research Field

口腔外科学

URL: 

Published: 2019-03-29  

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