2017 Fiscal Year Final Research Report
microRNA which promotes the diseminated tumor cell which participates in distant metastasis of the oral cancer
| Project/Area Number |
15K11295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 播種性腫瘍細胞 / 口腔癌 / microRNA |
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| Outline of Final Research Achievements |
The aim of this study was to verify whether microRNA participates for the object and making more disseminated tumor cell (DTC) a treatment mark. It's high seeding as an outcome, a tumor cell could do a thing with remote metastaticity clearly, and a possibility that miR-21 participates in the formative process was suggested. DKK2 was considered as a strong molecule as a mark molecule of miR-21. More DKK2 and manifestation of intercellular adhesion molecule were obstructed by miR-21 significantly, and a possibility that this mechanism participates in the special quality of DTC closely was suggested.
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| Free Research Field |
口腔腫瘍学
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