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2017 Fiscal Year Annual Research Report

The identification of drug resistance-related exosome microRNA and the applications for diagnosis and treatment in oral cancer

Research Project

Project/Area Number 15K11296
Research InstitutionKumamoto University

Principal Investigator

中山 秀樹  熊本大学, 大学院生命科学研究部(医), 教授 (70381001)

Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsマイクロRNA
Outline of Annual Research Achievements

【背景】近年、循環マイクロRNA(miRNA)が悪性腫瘍の進展や予後に関わる報告がなされ、化学放射線療法(CRT)の治療効果の予測や予後予測の新規マーカーとして期待されている。しかしながら、口腔扁平上皮癌(OSCC)におけるmiRNA発現の臨床的意義は十分示されておらず、臨床応用への道筋は未だ立っていない。そこで、本研究ではOSCC患者における循環miRNA発現に着目し、臨床的意義について検討を行った。
【方法】熊本大学医学部附属病院歯科口腔外科において治療を行い、血液サンプルが得られたOSCC患者55例を対象とした。全ての患者はS-1併用術前CRT 30Gyを施行した後に根治的手術を施行した。術前治療効果が良好/不良の2群間での循環miRNAの発現をマイクロアレイにて解析し、治療効果不良群で発現亢進を認めたmiRNAについて各種臨床項目との検討を行った。
【結果】miRNAマイクロアレイの結果より、miR-223、miR-659、miR-1290の3つのmiRNAが治療効果不良群で有意に上昇していることが明らかとなった。それらのmiRNAについて、OSCC患者55例を対象として血清中の各miRNA発現と臨床病理学的検討を行ったところ、miR-223高発現は局所再発、miR-659高発現はpT-stage、pN-stage、遠隔転移の有無と相関を認めた。一方、miR-1290発現量は分化度、CCRTの病理学的治療効果、再発の有無と有意に相関した。興味深いことに、miR-1290発現量は患者予後とも相関した。
【結論】循環マイクロRNAであるmiR-1290は、OSCC患者における術前CRTの治療効果予測と予後予測の有用なバイオマーカーとなる可能性がある。

  • Research Products

    (16 results)

All 2018 2017

All Journal Article (15 results) (of which Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018

    • Author(s)
      Tsuruta Miki、Ueda Shohei、Yew Poh Yin、Fukuda Isao、Yoshimura Sachiko、Kishi Hiroyuki、Hamana Hiroshi、Hirayama Masatoshi、Yatsuda Junji、Irie Atsushi、Senju Satoru、Yuba Eiji、Kamba Tomomi、Eto Masatoshi、Nakayama Hideki、Nishimura Yasuharu
    • Journal Title

      OncoImmunology

      Volume: 7 Pages: -

    • DOI

      10.1080/2162402X.2017.1415687

  • [Journal Article] Tumor budding as a novel predictor of occult metastasis in cT2N0 tongue squamous cell carcinoma2018

    • Author(s)
      Sakata Junki、Yamana Keisuke、Yoshida Ryoji、Matsuoka Yuichiro、Kawahara Kenta、Arita Hidetaka、Nakashima Hikaru、Nagata Masashi、Hirosue Akiyuki、Kawaguchi Sho、Gohara Shunsuke、Nagao Yuka、Hiraki Akimitsu、Shinohara Masanori、Toya Ryo、Murakami Ryuji、Nakayama Hideki
    • Journal Title

      Human Pathology

      Volume: 76 Pages: 1~8

    • DOI

      10.1016/j.humpath.2017.12.021

  • [Journal Article] Mucinous adenocarcinoma with signet ring cell features of the sublingual gland: A case report with an immunohistochemical analysis2018

    • Author(s)
      Nagata Masashi、Kusafuka Kimihide、Yoshida Ryoji、Kawahara Kenta、Nakagawa Yoshihiro、Nakamoto Masafumi、Shinohara Masanori、Nakayama Hideki
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: - Pages: -

    • DOI

      10.1016/j.ajoms.2017.12.008

  • [Journal Article] Severe interstitial pneumonia associated with anti-PD-1 immune checkpoint antibody after talc slurry pleurodesis2018

    • Author(s)
      Sakata Shinya、Matsuoka Yuichiro、Kawahara Kenta、Kakiuchi Yosuke、Takaki Akira、Hirosue Akiyuki、Yoshida Ryoji、Saeki Sho、Fujii Kazuhiko、Nakayama Hideki
    • Journal Title

      Respiratory Investigation

      Volume: 56 Pages: 195~198

    • DOI

      10.1016/j.resinv.2017.11.006

  • [Journal Article] Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma2018

    • Author(s)
      Shinriki Satoru、Jono Hirofumi、Maeshiro Manabu、Nakamura Takuya、Guo Jianying、Li Jian-Dong、Ueda Mitsuharu、Yoshida Ryoji、Shinohara Masanori、Nakayama Hideki、Matsui Hirotaka、Ando Yukio
    • Journal Title

      The Journal of Pathology

      Volume: 244 Pages: 367~379

    • DOI

      10.1002/path.5019

  • [Journal Article] The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells2017

    • Author(s)
      Nakamoto Masafumi、Ishihara Ko、Watanabe Takehisa、Hirosue Akiyuki、Hino Shinjiro、Shinohara Masanori、Nakayama Hideki、Nakao Mitsuyoshi
    • Journal Title

      PLOS ONE

      Volume: 12 Pages: -

    • DOI

      10.1371/journal.pone.0169225

    • Open Access
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion2017

    • Author(s)
      Takahashi Nozomu、Wei Fan-Yan、Watanabe Sayaka、Hirayama Mayumi、Ohuchi Yuya、Fujimura Atsushi、Kaitsuka Taku、Ishii Isao、Sawa Tomohiro、Nakayama Hideki、Akaike Takaaki、Tomizawa Kazuhito
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 435~445

    • DOI

      10.1093/nar/gkw745

  • [Journal Article] Prognostic impact of the level of nodal involvement: retrospective analysis of patients with advanced oral squamous cell carcinoma2017

    • Author(s)
      Murakami R.、Nakayama H.、Semba A.、Hiraki A.、Nagata M.、Kawahara K.、Shiraishi S.、Hirai T.、Uozumi H.、Yamashita Y.
    • Journal Title

      British Journal of Oral and Maxillofacial Surgery

      Volume: 55 Pages: 50~55

    • DOI

      10.1016/j.bjoms.2016.08.026

  • [Journal Article] A rare case of metachronous multiple supernumerary teeth in the bilateral premolar region of the mandible2017

    • Author(s)
      Koga Kan-ichi、Yoshida Ryoji、Nakamura Takuya、Matsuoka Yuichiro、Takeshita Hisashi、Takahashi Nozomu、Nakamoto Masafumi、Hiraki Akimitsu、Shinohara Masanori、Nakayama Hideki
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 29 Pages: 132~135

    • DOI

      10.1016/j.ajoms.2016.08.007

  • [Journal Article] Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia2017

    • Author(s)
      Sakata Junki、Yoshida Ryoji、Matsuoka Yuichiro、Nagata Masashi、Hirosue Akiyuki、Kawahara Kenta、Nakamura Takuya、Nakamoto Masafumi、Hirayama Masatoshi、Takahashi Nozomu、Nakashima Hikaru、Arita Hidetaka、Ogi Hidenao、Hiraki Akimitsu、Shinohara Masanori、Nakayama Hideki
    • Journal Title

      Cancer Medicine

      Volume: 6 Pages: 730~738

    • DOI

      10.1002/cam4.1005

  • [Journal Article] Notch1 in oral squamous cell carcinoma.2017

    • Author(s)
      Yoshida R, Ito T, Hassan WA, Nakayama H
    • Journal Title

      Histology and histopathology

      Volume: 32 Pages: 315~323

    • DOI

      10.14670/HH-11-821

  • [Journal Article] Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression2017

    • Author(s)
      Tsukamoto Hirotake、Fujieda Koji、Hirayama Masatoshi、Ikeda Tokunori、Yuno Akira、Matsumura Keiko、Fukuma Daiki、Araki Kimi、Mizuta Hiroshi、Nakayama Hideki、Senju Satoru、Nishimura Yasuharu
    • Journal Title

      Cancer Research

      Volume: 77 Pages: 2279~2291

    • DOI

      10.1158/0008-5472.CAN-16-2446

  • [Journal Article] Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report2017

    • Author(s)
      Kawahara Kenta、Hiraki Akimitsu、Yoshida Ryoji、Arita Hidetaka、Matsuoka Yuichiro、Yamashita Toshio、Koga Kan-Ichi、Nagata Masashi、Hirosue Akiyuki、Fukuma Daiki、Nakayama Hideki
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 6 Pages: 886~892

    • DOI

      10.3892/mco.2017.1226

  • [Journal Article] Concurrent chemoradiotherapy with S-1 in patients with stage III?IV oral squamous cell carcinoma: A retrospective analysis of nodal classification based on the neck node level2017

    • Author(s)
      Murakami Ryuji、Semba Akiko、Kawahara Kenta、Matsuyama Keiya、Hiraki Akimitsu、Nagata Masashi、Toya Ryo、Yamashita Yasuyuki、Oya Natsuo、Nakayama Hideki
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 7 Pages: 140~144

    • DOI

      10.3892/mco.2017.1276

  • [Journal Article] FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study2017

    • Author(s)
      Arita Hidetaka、Nagata Masashi、Yoshida Ryoji、Matsuoka Yuichiro、Hirosue Akiyuki、Kawahara Kenta、Sakata Junki、Nakashima Hikaru、Kojima Taku、Toya Ryo、Murakami Ryuji、Hiraki Akimitsu、Shinohara Masanori、Nakayama Hideki
    • Journal Title

      Tumor Biology

      Volume: 39 Pages: -

    • DOI

      10.1177/1010428317731771

  • [Presentation] Investigation of the clinical significance of circulating miRNA-1290 in oral squamous cell carcinoma.2017

    • Author(s)
      Nakashima H, Yoshida R, Matsuoka Y, Kawahara K, Sakata J, Arita H, Nagata M, Hirosue A, Nakayama H, Shinohara M
    • Organizer
      第29回台湾口腔顎顔面外科学会年次総会・学術集会

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Published: 2018-12-17  

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