2017 Fiscal Year Final Research Report
Identification of novel intra-cellular proteins binding to TPD54 protein
| Project/Area Number |
15K11301
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
近藤 誠二 昭和大学, 歯学部, 准教授 (10432634)
代田 達夫 昭和大学, 歯学部, 教授 (60235760)
|
|---|
| Research Collaborator |
KATO Kosuke 昭和大学, 歯学部
ITO Chihiro 昭和大学, 歯学部
MOTOHASHI Hiromi 昭和大学, 歯学部
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | TPD52ファミリー / TPD54 / 口腔癌 / 扁平上皮癌 |
|---|
| Outline of Final Research Achievements |
In the present study, we investigated the epigenetic post-translational regulation system of gene expression of TPD54, a member of TPD52 protein family. As well, we identified a novel intra-cellular protein, which binds to TPD54. These findings suggest a novel role of TPD54 protein as a molecular target for cancer theraputics. As a result, it was revealed that TPD54 regulates the secration of a certain secration protein, which is involved in proliferation and invasion of aquamous cell cartinoma (OSCC) cells, by the intra-cellular interaction; thereby it is suggested that this interaction might regulate the ability of proliferation and invasion of OSCC cells.
|
| Free Research Field |
口腔外科学
|
