2017 Fiscal Year Final Research Report
Development of a next generation type reconstruction method using biogradable magnesium alloy mesh
| Project/Area Number |
15K11305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山内 健介 東北大学, 歯学研究科, 准教授 (10364150)
清水 良央 東北大学, 歯学研究科, 助教 (30302152)
向井 敏司 神戸大学, 工学研究科, 教授 (40254429)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 生分解性 / マグネシウム合金 / 生体遺残 / 材料学的強度 / 顎骨再建 / 骨移植 / ピン |
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| Outline of Final Research Achievements |
To solve the problems concerning residues in the body and strength of the biomaterials, we performed a research of a next generation reconstruction method using biogradable magnesium alloy mesh and got the next results. 1. The living body safety was confirmed by in vitro cell toxicological test of a containing element and in vivo rat back subcutaneous transplantation. But the hydrogen gassing was confirmed by the absorption process. 2. Development of a bone transplantation fixed way by a biodegradablility magnesium alloy pin: A magnesium alloy pin of transplantation bone fixing (Mg pin) has been developed. It was possible to fix a bone fragment for 24 weeks by a Mg pin by an experiment of rabbit.No complications were observed in a follow up period for 6 months postoeprtively, and the healing process was excellent. Control of hydrogen gas which occurs in an absorption early stage of a Mg pin and consideration of surface design of the Mg pin seemed to be necessary.
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| Free Research Field |
医歯薬学
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