Bone/soft tissue regeneration technology with stem cells and the control of growth factor by autogenous fibrin

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MARUKAWA Eriko 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40419263)
• Research Collaborator: SASAKI Yoshihiro 京都大学, 工学研究科・高分子化学専攻, 准教授 ; AKIYOSHI Kazunari 京都大学, 工学研究科・高分子化学専攻, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: フィブリン / 成長因子制御 / 幹細胞

Outline of Final Research Achievements

I examined the influence on bone formation ability with controlled release of the BMP as growth factor by the CHP nano-gel. We were able to reduce the density of rhBMP-2 to 1μg using a rat bone ectopic model. In addition, I examined the ectopic bone induction of low-concentrated BMP-2/ CHP nano-gel/ β-TCP complex in the old age rat. We recognized the decrease of new bone area in all groups of old rats, and the new bone area decreased significantly in especially CHP nano-gel groups. Our result was suggested the possibility that bone formation was late by a controlled release effect with the CHP nano-gel. In the old age rat, enough results were not provided only by controlled release of BMP. We thought that it might be necessary to use cells such as stem cells.

Free Research Field

骨再生