Basic study of non-invasive detection system of oral cancer by molecular imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Gifu University
• Principal Investigator: Makita Hiroki 岐阜大学, 大学院医学系研究科, 講師 (50345790)
• Co-Investigator(Kenkyū-buntansha): 柴田 敏之 岐阜大学, 大学院医学系研究科, 教授 (50226172) ; 米本 和弘 岐阜大学, 医学部附属病院, 助教 (80422731)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔癌 / 早期癌 / 分子イメージング / グルコーストランスポーター１ / ラット舌癌モデル / バイオマーカー

Outline of Final Research Achievements

The purpose of this study is to establish non-invasive detection of oral precancerous lesion and early cancer by molecular imaging system. For new biomarker, we paid attention to glucose transporter 1 (GLUT1) , which increase with increasing cancerous characteristics. The imaging tests were performed using 4-NQ0 induced rat tongue cancer model and a new biomarker Glu-1N-Cy5 which transported in the cells by GLUT1. As a result of the molecular imaging tests, we could not get any pathological information about rat tongue carcinogenesis comparing an existing biomarker fluorescein sodium. However, this study was suggested possibility of a new detection system of oral cancer if more sensitive detection device was developed.

Free Research Field

口腔発癌