The Bone Regenerative effect of Osteoblasts on Novel Hydroxyapatite Ceramics and Study for Clinical application

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TADA MISATO (平岡) 広島大学, 病院(歯), 歯科診療医 (40572326)
• Co-Investigator(Kenkyū-buntansha): 武知 正晃 広島大学, 医歯薬保健学研究科(歯), 准教授 (00304535) ; 二宮 嘉昭 広島大学, 病院(歯), 助教 (60335685) ; 重石 英生 広島大学, 医歯薬保健学研究科(歯), 講師 (90397943)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 多孔質セラミックス / 骨再建材料 / 骨芽細胞 / ハイドロキシアパタイト

Outline of Final Research Achievements

Interconnected Porous Calcium Hydroxyapatite (IP-CHA) is an excellent ceramic for use in bone tissue engineering because of its fully interconnected porous structure, which allows osteoblasts disperion and supports their osteogenic differentiation. this study provided biochemical evidence that IP-CHA/osteoblasts composite and IP-CHA/osteoblasts/growth facters composite could enhance osteogenic potential. It was strongly suggested that IP-CHA was a useful biomaterials for bone tissue regeneration.

Free Research Field

口腔外科学