Development of bone regeneration method combining new carrier of bone marrow stromal cell culture system and cultured periosteum

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11317
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagoya City University
• Principal Investigator: Wada Keinoshin 名古屋市立大学, 大学院医学研究科, 研究員 (10533755)
• Co-Investigator(Kenkyū-buntansha): 尾島 泰公 名古屋市立大学, 大学院医学研究科, 研究員 (40403240) ; 渋谷 恭之 名古屋市立大学, 大学院医学研究科, 教授 (90335430)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨再生 / チタン / 成長因子

Outline of Final Research Achievements

There is a problem that surgical invasion to the donor is large in restoration of the bone defect. Therefore, we examined the usefulness of a new bone regeneration method using a novel carrier excellent in cell adhesiveness, and aimed to regenerate the same bone form as the removed bone. It is considered that bone marrow stromal cell culture system, development of new cell carrier, and purification of cultured periosteum by new technology are essential items for the new bone regeneration. Therefore titanium mesh into a cylindrical shape was placed on the skull of the rabbit in order to confirm the utility as a scaffold, and platelet fibrin (Platelet-rich fibrin; PRF) containing a lot of growth factors and cytokines was put with a film shape which was investigated whether it could be used as a substitute for a new gelatin sponge, while significant new bone regeneration could not be observed.

Free Research Field

口腔外科学