2017 Fiscal Year Final Research Report
DNA methylation status of oral lichen planus
| Project/Area Number |
15K11319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Yada Naomi 九州歯科大学, 歯学部, 准教授 (60468022)
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| Research Collaborator |
YOSHIMURA Kurara
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口腔扁平苔癬 / ＤＮAメチル化 / SOCS１ / SOCS3 |
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| Outline of Final Research Achievements |
Oral lichen planus (OLP) is a disease of unknown etiology affecting oral mucosa by mediated chronic inflammation and is classified as a potentially malignant oral disorder. SOCS3 in the SOCS family have been identified as negative regulators of the cytokine-activated JAK/STAT pathway responsible for inflammatory reaction and carcinogenesis. SOCS3 was methylated in 25/29 (86.2%) cases with OLP. DNA methylation status of SOCS3 were negatively correlated with the expression level of SOCS3 mRNA. We posit frequent methylation of the SOCS3 gene promoter, theoretically resulting in the increase of cytokines expression, might be associated with the etiological mechanism of OLP.
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| Free Research Field |
口腔病理
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