Role of the endothelin in oral cancer related pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11320
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: HARANO NOZOMU 九州歯科大学, 歯学部, 講師 (50423976)
• Co-Investigator(Kenkyū-buntansha): 小野 堅太郎 九州歯科大学, 歯学部, 教授 (40316154) ; 人見 涼露 九州歯科大学, 歯学部, 助教 (70548924)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Orofacial pain / Oral Pathology / Inflammation / Neuropharmacology / Neuroscience / Infectious disease

Outline of Final Research Achievements

ET-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. In the present study, we investigated the involvement of ET-1 signaling with oral ulcer-induced pain using our proprietary assay system in conscious rats.
ET-1 upregulation following oral bacterial invasion via the ulcerative region elicits TRPA1-mediated spontaneous pain due to ETB receptor-accelerated prostanoid production, and TRPA1- and TRPV1-mediated mechanical allodynia via both ETA and ETB receptors, while ET-1-indepedent pathways also induce pain
in the model. The findings highlight the potential of endothelin signaling blockers as effective analgesics for oral ulcer patients, together with the significant analgesic effects of the clinically available drug bosentan.

Free Research Field

歯科麻酔学