Development of novel therapeutic methods using Botox for masseter muscle pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: NOMA Noboru 日本大学, 歯学部, 准教授 (70386100)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性疼痛 / ION-CCI / P-ERK

Outline of Final Research Achievements

We investigated the effect of botulinum neurotoxin type A (BoNT-A) on mechanical allodynia and　hyperalgesia associated with infraorbital nerve constriction (ION-CCI) in rats. ION-CCI rats received a subcutaneous BoNT-A injection into the whisker pad area on day 7 postoperatively and underwent pain assessment on days 14 and 21 postoperatively. Rats were assigned to one of four treatment groups(n = 5 each): ION-CCI + BoNT-A 20 pg (low-dose group), ION-CCI + BoNT-A 200 pg (high-dose group), IONCCI+ saline, and Sham. Mechanical allodynia and hyperalgesia were evaluated preoperatively (baseline) and on days 7, 14, and 21 postoperatively. BoNT-A administration. The present findings suggest that, by suppressing Vc neuronal activity, high-dose intradermal injection of BoNT-A at the site of ION innervation alleviates mechanical facial allodynia and hyperalgesia associated with ION-CCI.

Free Research Field

口腔顔面痛