2017 Fiscal Year Final Research Report
Elucidation of the structural change-related factor in the bone microenvironment
| Project/Area Number |
15K11332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浦出 雅裕 兵庫医科大学, 医学部, 特別招聘教授 (70104883)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 骨微小環境 / 破骨前駆細胞 / TGF-β |
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| Outline of Final Research Achievements |
Osteoclasts (OC) are differentiated from monocyte/macrophage-lineage hematopoietic precursor cells which were termed OC precursors (OCPs). The aim of this study was to determine the effects of TGF-β on migration of OCPs in the bone microenvironment using the pre-osteoclastic RAW264.7 cells. Cell migration was significantly increased by treatment of TGF-β1 on 24 h, but was decreased by 72 h of treatment. These findings suggest that the migration of OCPs was enhanced by TGF-β1 at early stages of osteoclast differentiation, and at later stages differentiated cells showed low migration. The cell migration change might be caused by osteoclast differentiation. Subsequently, migration gradually decreases following differentiation.
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| Free Research Field |
口腔外科学
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