The role of neuron-glial cells crosstalk within the trigeminal ganglion in orthodontic pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Azabu University
• Principal Investigator: Yoshihito Shimazu 麻布大学, 生命・環境科学部, 准教授 (10297947)
• Co-Investigator(Kenkyū-buntansha): 武田 守 麻布大学, 生命・環境科学部, 教授 (20227036)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯の矯正移動 / ラット / 臼歯 / 疼痛 / 三叉神経節 / ニューロン / グリア細胞 / 免疫組織化学

Outline of Final Research Achievements

The aim of the present study was to investigate the functional role of neuron-glial cells crosstalk within the trigeminal ganglia on the enhancement of neuronal excitability of trigeminal ganglion in experimentally tooth-movement (ETM) rat, using behavioral, electrophysiological and immunohistochemical studies. In the present study, we established ETM rat model for examining orthodontic pain. Behavioral analysis revealed that occurrence of spontaneous pain and ectopic hyperalgesia in the whisker pad area was observed in the maxillary ETM rat. Electrophysiological study demonstrated that mechanical discharge frequency of trigeminal spinal nucleus caudalis neurons in the ETM rats was significantly increased due to the decrement of mechanical stimulus threshold. Taken together, these findings strongly suggest that neuron-glial cells crosstalk within the trigeminal ganglia may contribute to the ETM-induced ectopic inflammatory hyperalgesia.

Free Research Field

矯正・小児系歯学