Application of modificomic technologies to discover and identify biomarkers for periodontal diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Chiba University
• Principal Investigator: Tsuchida Sachio 千葉大学, 医学部附属病院, 特任助教 (90410422)
• Co-Investigator(Kenkyū-buntansha): 佐藤 守 千葉大学, 医学部附属病院, 特任准教授 (20401002)
• Co-Investigator(Renkei-kenkyūsha): Aoki Akira 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (30302889) ; Kobayashi Hiroaki 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50396967)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯学 / 歯周病学 / プロテオミクス / 質量分析計

Outline of Final Research Achievements

Proteomics provides a better understanding of cells by elucidating the structure, function, and interactions of proteins. Furthermore, post-translational modification (PTM) of proteins is required to control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms, it is critical to profile the PTM-dependent protein- protein interactions. Our findings indicate that PTM of protein may be involved in the progression of periodontal disease and is a potential biomarker of periodontal disease. Further studies using a larger sample size are required to verify the findings of this study. In the future, phosphoproteomics and glycomics may be applied to the study of periodontal disease.

Free Research Field

歯周治療系歯学