Looking for a periodontal flame clinical condition formation mechanism from IL-17C.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Niigata University
• Principal Investigator: Ito Harue 新潟大学, 医歯学系, 助教 (30397145)
• Co-Investigator(Kenkyū-buntansha): 中島 貴子 新潟大学, 医歯学系, 講師 (40303143)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周炎 / IL-17C

Outline of Final Research Achievements

Periodontitis is caused by bacterial infection. However, the periodontal tissue destruction and alveolar bone resorption are caused by the host immune responses. Recently it has been reported that interleukin (IL)-17 has important role in autoimmune diseases and inflammatory diseases. Therefore, we focused on IL-17C which is one of the family molecules of IL-17, and attempted to clarify its involvement and role in the pathogenesis of periodontitis. We observed that the gene expression of IL-17C and IL-17RE which is its receptor, in human gingival epithelial cells. And the gene expression of IL-17C increased by bacterial antigen stimulation. This suggested that IL-17C is involved in the pathogenesis of periodontitis.

Free Research Field

歯周病学