role of melatonin in periodontal disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: The University of Tokushima
• Principal Investigator: HOSOKAWA Ikuko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (50707908)
• Co-Investigator(Kenkyū-buntansha): 中西 正 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (00217770) ; 細川 義隆 徳島大学, 病院, 講師 (90346601)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周炎 / メラトニン / MMP-1 / CXCL10

Outline of Final Research Achievements

We examined the effect of melatonin on CXCL10 and MMP-1 productions from IL-1β-stimulated human periodontal ligament cells (HPDLC) in this study. We found that melatonin could inhibit CXCl10 and MMP-1 producutions from IL-1β-stimulated HPDLC. Therefore, melatonin could the initiation and progression of periodontal disease by controlling chemokine and MMP production in periodontal lesions.

Free Research Field

歯周治療系歯学