Novel role of osteocytes in periodontal disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Kagoshima University
• Principal Investigator: Sena Kotaro 鹿児島大学, 医歯学域歯学系, 助教 (60701117)
• Co-Investigator(Kenkyū-buntansha): 迫田 賢二 鹿児島大学, 医歯学域歯学系, 助教 (70419654) ; 町頭 三保 鹿児島大学, 医歯学総合研究科, 客員研究員 (80253897)
• Co-Investigator(Renkei-kenkyūsha): MACHIGASHIRA Miho 鹿児島大学, 医歯学総合研究科, 客員研究員 (80253897)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周病 / 骨細胞

Outline of Final Research Achievements

Recently, osteocytes have been reported to play an important role in bone metabolism which indicates osteocytes may play a role in periodontal disease. In this project, we determined the mechanism how lipopolysaccharide isolated from Porphyromonas gingivalis（Pg-LPS）induced cytokine production by osteocytes. We further performed global analyses for Pg-LPS induced gene expression. Current findings suggest involvement of osteocytes in advanced periodontal disease with alveolar bone resorption by inducing cytokine production in response to periodontal pathogen.

Free Research Field

歯周病学