The comprehensive survey for the risk factor of oral mucositis under the radiotherapy.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11409
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Hosokawa Ryoichi 東北大学, 医学系研究科, 非常勤講師 (40547254)
• Co-Investigator(Kenkyū-buntansha): 小関 健由 東北大学, 歯学研究科, 教授 (80291128) ; 末永 華子 東北大学, 歯学研究科, 助教 (00508939) ; 菅崎 将樹 東北大学, 大学病院, 助教 (50444013) ; 玉原 亨 東北大学, 歯学研究科, 助教 (40756235) ; 丹田 奈緒子 東北大学, 大学病院, 助教 (00422121) ; 佐久間 陽子 東北大学, 歯学研究科, 助教 (90735531) ; 伊藤 恵美 仙台青葉学院短期大学, 歯科衛生学科, 准教授 (80596817)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん支持療法 / 口腔粘膜炎 / 漢方

Outline of Final Research Achievements

It is very important to prevent or reduce adverse events caused by the radiotherapy and chemotherapy for completing the treatment plan. Especially, the adverse events of head and neck cancer caused by radiotherapy are very severe. For instance, patients complain dry mouth　and oral mucositis so on. Oral mucositis cause severe pain and reduce patient’s quality of life. It is very hard for patients to eat or talk due to the pain caused by oral mucositis. So it is requested to establish the methods inhibit oral mucositis during radiotherapy.
In this study, we proposed the possibility to reduce the severity of oral mucositis using Hangeshasinto, which is one of traditional medicine in Japan in clinical study. Also we provide the mechanism how Hangeshasinto prevent oral mucositis by using cell culture experiments.

Free Research Field

がん支持療法