Development of rheumatoid arthritis prevention method targeting P. gingivalis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka University
• Principal Investigator: SEKINE Shinichi 大阪大学, 歯学部附属病院, 講師 (70506344)
• Co-Investigator(Kenkyū-buntansha): 久保庭 雅恵 大阪大学, 歯学研究科, 准教授 (00303983) ; 永田 英樹 関西女子短期大学, 歯科衛生学科, 教授 (50260641)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: P. gingivalis / ベジクル / 細菌叢 / POCT

Outline of Final Research Achievements

We examined how P. gingivalis which is an oral bacterium affects the tissue outside the oral cavity. Vesicles containing all toxic substances such as PAD, gingipain and LPS promoted expression of inflammatory cytokines in gingival cells. P. gingivalis itself also altered the intestinal flora outside the oral cavity. We also attempted immediate detection of Pg outside the oral cavity and could be achieved by using a capillary electrophoresis system.

Free Research Field

予防歯科