The study of the periodontal tissue regeneration medicine by the plasenta

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: OH Hourei 大阪歯科大学, 歯学部, 教授 (20213613)
• Co-Investigator(Kenkyū-buntansha): 益野 一哉 大阪歯科大学, 歯学部, 准教授 (40288775)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胎盤製剤 / プラセンタ / 歯周疾患 / 抗炎症作用 / 細胞増殖能 / コラーゲン産生能 / ALP / 歯周組織再生能

Outline of Final Research Achievements

Placental extract, which contains various bioactive agents, is thought to be a prospective medicine for systematic and oral diseases. However, in-depth information regarding its mechanisms with respect to treating periodontal diseases is not available, thereby hindering its reliable application in dentistry. Firstly,this study demonstrated that P-placental extraction, isolated from porcine tissue, increased collagen type-1 production and hindered pro-inflammatory cytokine secretion from human gingival fibroblasts in vitro． Next,the study examined the effect of the extract on cellular metabolism of osteoblastic cell line Saos-2 cells. Here we demonstrated that the placenta at the optimal dosage enhanced the proliferation, collagen type 1 production, and alkaline phosphatase secretion of Saos-2 in vitro. From these results, it is　suggest that the placenta have anti-inflammatory and periodontal tissue regeneration on periodontal disease.

Free Research Field

臨床薬理学