Development of a fundamental concept for manipulating biomolecular motors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12135
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: Hokkaido University
• Principal Investigator: Kakugo Akira 北海道大学, 理学研究院, 准教授 (10374224)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体分子モーター / 物質輸送 / DNA

Outline of Final Research Achievements

Biomolecular motors are molecular machines with high efficiency and high specific power. In this research, we develop a fundamental concept for manipulating a large number of biomolecular motors. As an application, we propose creation of a system that could actively transport and accumulate target substances in groups.
In order to realize this concept, we established a methodology that controlled transportation of target substances by using biomolecular motor and DNA which allowed precise control of intermolecular interaction based on base DNA sequence information. Furthermore, by introducing photoresponsive DNA, we constructed a system that could manipulate the transportation of the target substances using light.

Free Research Field

生物物理・ソフトマター