A mathematical study on artificial stimulation to pancreas in type 2 diabetes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12137
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: University of Tsukuba
• Principal Investigator: ANDO Hiroyasu 筑波大学, システム情報系, 准教授 (20553770)
• Co-Investigator(Kenkyū-buntansha): 藤原 寛太郎 東京理科大学, 工学部情報工学科, 助教 (00557704)
• Co-Investigator(Renkei-kenkyūsha): KAKEI Masafumi 自治医科大学, 医学部, 研究員 (90214270) ; IKEGUCHI Tohru 東京理科大学, 工学部, 教授 (30222863)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膵β細胞 / 力学系理論 / 発火パターン / イオンチャンネル

Outline of Final Research Achievements

In this research project, in order to develop a new remedy for type 2 diabetes, we propose a model of electric stimulation to pancreas. In particular, we investigate a mathematical model of a pancreatic beta cell which is related to insulin secretion for controlling blood glucose level. We obtained the following two results. 1) We observed a phenomenon promoting insulin secretion by simulating a reaction of beta cells to white Gaussian noise, that is, the frequency of bursting of the beta cell increases with increasing the amplitude of noise. 2) We proposed a model of the background current of the beta cell and reproduced behavior of the beta cell by simulation consistent with the experiment of the background current.

Free Research Field

数理情報学