Explore of molecular aerials sensitizing radiobiological effects

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12211
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: National Institutes for Quantum and Radiological Science and Technology (2016); Japan Atomic Energy Agency (2015)
• Principal Investigator: Yokoya Akinari 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (10354987)
• Co-Investigator(Renkei-kenkyūsha): FUJII KENTARO 量子科学技術研究開発機構, 東海量子ビーム応用研究センター, 上席研究員 (00360404)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: Brウラシル / DNA損傷 / ハロゲンによる放射線増感 / 電子状態 / 熱容量測定 / 単結晶 / プラスミドDNA

Outline of Final Research Achievements

The aim of this study is to explore molecular aerials which sensitize radiobiological effects. Radical measurement experiments using an EPR apparatus revealed that the electron attraction to bromine atom would play an important role in the radical process in DNA. It was inferred that the number of microscopic states increases with existence of a bromine atom. Furthermore, DNA damage of double strand breaks (DSBs) in Br-incorporated plasmid were also enhanced by 20 % when exposed to X-rays. Monte Carlo track simulation indicates that the enhancement of DSBs could be induced by charge migration along a DNA molecule. These evidences show that the electronic state around bromine atom is characteristic to specify its molecular aerial nature.

Free Research Field

放射線生物物理学