The study on the low dose radiation on oxidative stress and cardiovascular systems on maice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12212
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: National Institute of Public Health
• Principal Investigator: USHIYAMA Akira 国立保健医療科学院, 生活環境研究部, 上席主任研究官 (60291118)
• Co-Investigator(Kenkyū-buntansha): 志村 勉 国立保健医療科学院, 生活環境研究部, 上席主任研究官 (40463799) ; 服部 研之 明治薬科大学, 薬学部, 講師 (90306663)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生物影響 / 低レベル放射線 / 微小循環 / 生体顕微鏡 / 酸化ストレス

Outline of Final Research Achievements

To investigate the scientific basis of risk leading to cardiovascular disorders due to radiation exposure, we used the intravital microscope system, which is possible to observe the microcirculatory dynamics of the same region for long time.
We clarified the influence on the circulation index. In addition, oxidative stress caused by radiation exposure was visualized by detecting oxidative stress response by luminescence imaging, and the relationship between oxidative stress response generation site and circulatory dynamics was examined.

Free Research Field

環境生理学　循環生理学