Establishment of a screening system to select cancer preventive ingredient based on a new carcinogenesis theory

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12329
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Toyo University
• Principal Investigator: YANO TOMOHIRO 東洋大学, 食環境科学部, 教授 (50239828)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: がん幹細胞 / 前立腺がん / がん予防食素材

Outline of Final Research Achievements

In this study, I tried to establish the system which screened preventive ingredients which was effective for the primary and second prevention of the prostate cancer based on cancer stem cell theory that was a new carcinogenesis theory. Using the new three-dimensional culture method and a special medium to stimulate cancer stem cell formation, I succeeded in the establishment of the prostate cancer stem cell separation method with sphere formation ability as an index. Utilizing this isolated prostate cancer stem cell, I showed that annatto tocotrienol (delta-tocotrienol more than 90% component), which the possibility as prostate cancer preventive ingredient had been already shown in previous studies, could be effective to inhibit prostate cancer stem cell growth. Through this study, I established the screening system to select new prostate cancer preventive ingredients based on a cancer stem cell theory.

Free Research Field

がん病態制御学