F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12339
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kobe University
• Principal Investigator: Mizuno Masashi 神戸大学, 農学研究科, 教授 (00212233)
• Co-Investigator(Kenkyū-buntansha): 橋本 堂史 神戸大学, 農学研究科, 准教授 (90362764)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Ⅰ型アレルギー / フコイダン / コンブ / ガレクチン９

Outline of Final Research Achievements

It was demonstrated that oral administration of F-fucoidan from Saccharina japonica possessed anti-allergic effects using the passive cutaneous anaphylaxis (PCA) reaction, but not by intraperitoneal administration. Oral administration of F-fucoidan at least for 7 days started after 2nd or 4th sensitization with OVA/Al(OH)3 inhibited reduction of rectal temperature induced by activation of mast cells in OVA. F-fucoidan increased galectin-9 mRNA expression in colonic epithelial cells. These results suggested that F-fucoidan could suppress the allergic symptoms in sensitized mice by inducing galectin-9 production from colonic epithelial cells. In conclusion, it was suggested that F-fucoidan might become an effective therapeutic agent for patients already developed type I allergic diseases.

Free Research Field

食品化学