Functional analysis for lifestyle diseases-related molecules based on molecular epidemiologic study

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12342
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Nagasaki University
• Principal Investigator: MORI Ryoichi 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30509310)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: miRNA / Foxo / カロリー制限

Outline of Final Research Achievements

MicroRNAs (miRNAs) of the small, non-coding RNA family that regulate translational processing of target mRNAs. miRNAs in fluid might be associated with diseases and application to biomarker. However molecular and cellular mechanisms are largely unknown. In this study, we have identified lifestyle diseases-related miR-22-3p using molecular epidemiologic study. And we clarified that age-related transcription factor Foxo3a regulates expression level of miR-22-3p in serum.

Free Research Field

炎症学、組織再生学、老化学