Functional analysis of WDR6, a novel energy metabolism related gene

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12349
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Waseda University
• Principal Investigator: CHIBA Takuya 早稲田大学, 人間科学学術院, 教授 (40336152)
• Co-Investigator(Kenkyū-buntansha): 下川 功 長崎大学, 医歯薬学総合研究科(医学系), 教授 (70187475) ; 大畑 佳久 早稲田大学, 人間科学学術院, 助手 (60779289)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: インスリンシグナル / 老化 / 老化関連疾患 / オートファジー / カロリー制限 / 遺伝子改変動物

Outline of Final Research Achievements

Insulin signal is one of the major regulatory signals of aging process. We have been reported that WDR6 (WD repeat protein 6) functions as a novel insulin signal molecule. In this research, we showed that WDR6 is involved in mTORC1 pathway whish is important for cell growth and autophagy regulation by using WDR6 knock out mice and WDR6 knock down cells. These results suggest that WDR6 might have important roles in the longevity regulation in higher organisms.

Free Research Field

実験病理学