2016 Fiscal Year Final Research Report
Acoustic Diagnosis of Bone Fracture Risks Based on the Conception [Bone fatigue fracture is a result of the degradation of bone quality due to microdamage accumulation]
| Project/Area Number |
15K12516
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 疲労骨折 / 骨粗鬆症 / 骨量 / 骨質 / 骨折リスク / 音響診断 |
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| Outline of Final Research Achievements |
Osteoporotic model femur specimens were obtained from rats at 13 or 19 weeks after ovariectomization. In order to evaluate the bone mass and bone quality, the measurement of ultrasonic propagation characteristics, X-ray CT photography and dynamic mechanical analysis (DMA) were carried out. Furthermore, 4-point bending tests and static compression tests of control and osteoporotic model femur specimens were performed. During the tests, microdamage accumulation of rat femur was monitored by acoustic emission. Consequently, it was found that the influence of ovariectomization was more significant for proximal rather than diaphysis.
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| Free Research Field |
生体力学、材料評価工学
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