Analysis of interaction between polyampholytes and lipid membranes to reveal mechanisms of cell cryopreservation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12538
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: Hamada Tsutomu 北陸先端科学技術大学院大学, 先端科学技術研究科, 准教授 (40432140)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: バイオマテリアル / 脂質2分子膜

Outline of Final Research Achievements

Cryopreservation of cells is one of important technologies for regenerative medicine. Here, we focus on the interaction between polyampholytes and lipid membranes to clarify the mechanism of cell freezing and develop new materials. We found the improvement of cryoprotective function by introducing hydrophobic moiety into a polyampholyte, phase diagram of the polymer, adsorption behavior of the polymer on the membrane, and electrostatic effects on membrane structures.

Free Research Field

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