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2016 Fiscal Year Final Research Report

Signal-responsive biomaterials for wound healing

Research Project

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Project/Area Number 15K12543
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNara Women's University

Principal Investigator

HASHIMOTO Tomoko  奈良女子大学, 生活環境科学系, 助教 (10589930)

Research Collaborator NAKAMURA Yuka  
YAMAOKA Tetsuji  
KAMEDA Tsunenori  
TAMADA Yasushi  
KUROSU Hiromichi  
Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsシルクフィブロイン / 機能性ペプチド
Outline of Final Research Achievements

In this study, it was found that peptides contain (GAGAGS)n sequences immobilized on silk fibroin specifically. Solid-state 13C CP/MAS NMR, FTIR-ATR, Raman imaging spectroscopy and Differential scanning calorimetry were performed to investigate secondary structures and thermal properties of silk fibroin molecules. These results indicated that beta-sheet contents in silk fibroin films influenced the immobilization efficiency of peptides.
Novel hybrid peptides composed of (GAGAGS)n sequences, cleavable sequences and wound healing sequences were designed and synthesized. Immobilizations and cleavages of fluorescence-labeled hybrid peptides were evaluated.

Free Research Field

生体材料

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Published: 2018-03-22  

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