Development of non-invasive super rapid lymph node biopsy system

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12555
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Chiba University
• Principal Investigator: Yamaguchi Tadashi 千葉大学, フロンティア医工学センター, 教授 (40334172)
• Co-Investigator(Renkei-kenkyūsha): HAYASHI Hideki 千葉大学, フロンティア医工学センター, 教授 (20312960) ; YOSHIDA Kenji 千葉大学, フロンティア医工学センター, 助教 (10572985)
• Research Collaborator: MAMOU Jonathan Riverside Research, Lizzi Center for Biomedical Engineering, Research Manager ; CORON Alain Laboratoire d'Imagerie Biomédicale, CNRS, Researcher
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 超音波 / 乳がん / センチネルリンパ節 / 術中迅速診断

Outline of Final Research Achievements

We constructed a system capable of transmitting and receiving ultrasonic waves to the living tissue under arbitrary conditions at first. In this system, not only ultrasonic observation in the living tissue but also measurement of various substances including the extracted biological specimen is also possible. For the living tissues under each condition, the structural analysis of the internal part of the lymph node developed by the applicant and the degeneration evaluation algorithm at the cell level were applied, and the characteristic acoustic characteristics of each organization were analyzed.
Plurality of ultrasonic probes to be used in conjunction with the above-described system were prepared, and the living tissue measurement was made possible by using an ultrasonic beam suitable for the observation target.　In addition, we proposed a robust signal compensation and analytical method considering mixing of noise caused by acoustic wave propagation in the living tissue.

Free Research Field

人間医工学