2016 Fiscal Year Final Research Report
Multi-functional probe type pH sensor for intracellular or cell surface sensing
| Project/Area Number |
15K12560
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | マイクロニードル / pHセンサ / 温度センサ / 単一細胞 |
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| Outline of Final Research Achievements |
The detection of temperature and pH at the single-cell level is hoping for the great level of clinical importance for the early detection of many diseases like cancer, diabetes, etc. In this research work, we have fabricated a micro region pH and temperature sensors by series of processes like electrolytic polishing to create needle structure, deposition of electrode materials using sputtering for measurements and finally testing in various biological medium. The fabricated tip of the microneedle probe is nearly 5μm analyzed by laser microscope. pH testing was evaluated using fish egg and the found that results were significant. Seebeck co-efficient observed for the micro region temperature sensors is relatively low compared to theoretical values. The vibration of the needle to inject into a cell can make apparent young’s modulus larger so that the injection force for cell will be reduced.
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| Free Research Field |
医用工学
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