Lubricity evaluation of articular cartilage by spectroscopic characterization of dispersion and/or aggregation of Au nanoparticles

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12565
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: National Defense Medical College
• Principal Investigator: Ishihara Miya 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医用工学, 教授 (30505342)
• Co-Investigator(Renkei-kenkyūsha): TERANISHI Toshiharu 京都大学, 科学研究所, 教授 (50262598) ; SATO Masato 東海大学, 医学部, 教授 (10056335)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 検査・診断システム / 変形性関節症 / 関節鏡 / ナノ粒子 / 摩擦係数 / 粘弾性係数

Outline of Final Research Achievements

In order to promote a prosperous aging society, maintaining our ADL (Activity of daily life) is important. For this purpose, noninvasive measurements of articular cartilage functions are required. We developed diagnostic methods of viscoelasticity and biochemical characteristics using optical measurement. In this research, an optical method of evaluation of the third function of articular cartilage, lubrication, was designed. We strategically focused on the hyaluronic acid, which performs the function of lubrication, has specific charge state distribution. We used gold nanoparticles with various surface modifications. As results, we could characterize their charge spectroscopically. This spectroscopic measurement method has a possibility of sharing with the method of biochemical analyses of extracellular matrix of articular cartilage. Therefore, we found the potential to evaluate lubrication and biochemical characterization of the articular cartilage simultaneously.

Free Research Field

医用生体光学