Effects of chronic exercise in polycystic kidney rats

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12573
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO OSAMU 東北大学, 医学系研究科, 大学院非常勤講師 (00361072)
• Co-Investigator(Kenkyū-buntansha): 森 信芳 東北大学, 医学系研究科, 助教 (50463790) ; 上月 正博 東北大学, 医学系研究科, 教授 (70234698) ; 小川 佳子 帝京大学, 医療技術学部, 助教 (90733791)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リハビリテーション / 腎臓 / 循環器・高血圧 / ストレス / 細胞・組織

Outline of Final Research Achievements

The present study assessed the effects of chronic exercise on renal function and cystic formation in polycystic kidney disease(PKD) model. Six-week-old male polycystic kidney (PCK) rats were divided into the sedentary group and chronic exercise group (n=10 in each group). Chronic exercise underwent forced treadmill running for 12 weeks. Ex significantly reduced proteinuria and plasma creatinine, and it ameliorated glomerular sclerosis, podocyte injury and cyst formation and interstitial fibrosis not only in kidney but also in liver. These results indicate that chronic exercise ameliorates glomerular injury, cystic formation and fibrosis in the kidney and liver of PCK rats. Chronic exercise may be a new therapeutic approach for PKD.

Free Research Field

リハビリテーション医学