TMS and Intensive therapy for PD

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12587
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Jikei University School of Medicine
• Principal Investigator: ABO MASAHIRO 東京慈恵会医科大学, 医学部, 教授 (00266587)
• Co-Investigator(Kenkyū-buntansha): 木村 郁夫 東京慈恵会医科大学, 医学部, 助教 (40724399)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: パーキンソン病 / 反復性経頭蓋磁気刺激 / UPDRS / Hoehn and Yahr scale / ABMS / バランストレーナー / 非運動症状

Outline of Final Research Achievements

As for the evaluation of Parkinson's disease, Hoehn and Yahr scale, UPDRS　are popular. However, we point out the need to make up for two evaluations that cannot accomplish a standing position in a relation from getting up by some kind of methods in accomplishing physical therapy. Ability for Basic Movement Scale (ABMS) was detected as meaningful relations only in movement in Hoehn and Yahr scale and a start by the result of the multiple regression analysis.
We assessed the effect of rTMS therapy on 2 PD patients with different backgrounds. After 1 month, the scores of UPDRS part III had changed from 34 to 28 in case 1, and from 19 to 11 in case 2, respectively.
The severity of motor symptoms and the anxiety improved in the short term. The rTMS therapy might be effective in improving motor and non-motor symptoms with potential benefit for PD patients. Further observations would be needed to clarify the effectiveness of rTMS for PD patients.

Free Research Field

リハビリテーション医学