The contribution of mechanical stress to cell functions to lead neural plasticity in spinal cord.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12591
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Rehabilitation Center for Persons with Disabilities
• Principal Investigator: OGATA TORU 国立障害者リハビリテーションセンター(研究所), 病院(併任研究所) 障害者健康増進・運動医科学支援センター, センター長 (00392192)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 脊髄損傷 / メカニカルストレス

Outline of Final Research Achievements

Induction of neural plasticity is thought of as one mechanism of neuro-rehabilitation for the treatment of spinal cord injury. Various factors including tissue environmental factors control to the neural cell function, which affects neural plasticity. However it is not clear that neural tissue rigidity, one putative element of the tissue environmental factors, contributes to the neural cell functions as mechanical stress signaling. In this study, we focused on p130Cas, which is previously reported as a mechanosensor and showed that p130Cas expresses in Iba1-positive microglia in spinal cord and might contribute to the inflammatory response following tissue injury.

Free Research Field

リハビリテーション医学